Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

Abstract In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a ‘bottom-up’ method and fully characterized by X-ray diffraction, infrared spectroscopy relaxivity measurements. Two cytotoxic agents then intercalated ion-exchange. diffraction patterns exhibit expanded interlayer spacings as result of successful drug intercalation. Infrared spectra also showed characteristic peaks the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs found to be highly stable under physiological conditions, while in acidic conditions small proportion Gd was freed into immersion medium. Dissolution tests revealed that both 5FU MTX rapidly released from LDH carrier. longitudinal Gd-LDHs remains largely during release over 24 h, higher environments. Overall, drug-loaded Gd-LDH systems prepared study could serve pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.